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Symbol: Pro P
Molecular Weight: 115.13
Isolectric point (pH) 6.30
Molecular Formula: C 5H9NO2
Proline is one of the
twenty amino acids that are used by
living organisms as a building block of proteins (so called proteinogenic amino acids).
Proline is one of the cyclic aliphatic amino acids that is a
major component of the protein collagen, the connective tissue
structure that binds and supports all other tissues. Proline
is synthesized from glutamic acid prior to its incorporation
into pro-collagen during messenger RNA translation.
In proteins, proline can act as a structural
disruptor for (α) helices,
and as a turning point in β sheets. Multiple prolines
in a row can create a proline helix. Sequences of proline
and 1-Aminosiobutyric acid (Aib) form a helical turn structure.
Incorporated into peptides proline forms
a tertiary amide. It doesen't have a hydrogen on the amide group
and can therefore not act as a hydrogen
bond donor.
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