The interaction between Val 6 (left) on one chain of one hemoglobin molecule and a hydrophobic patch formed by Phe 85 (top right) and Leu 88 (bottom right) on a chain of another deoxygenated hemoglobin molecule leads to hemoglobin aggregation.

Read more about Hemoglobin S

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PDB File for Hemoglobin S Molecule click here.